@fshakhverdiyev Thanks for the additional info. It's still hard to help based on the limited information above though.
What is the exact code that you use to switch skins and enable/disable ragdolls that leads to your issue?
What does your skin setup look like before and after the problematic switching?
Do you have skin-bones which are present in one skin and not present in another?
What does your bone hierarchy look like in Spine at the problematic skin, and how does the respective SkeletonUtilityBone
hierarchy look like in the Unity Hierarchy window?